4-Phenylpiperidine → 3-(4-Phenyl-1-piperidinyl)pyridine

HRID 1346075ノート

反応式

HRID 1346075 の反応式
Ic1cccnc1.c1ccc(C2CCNCC2)cc1>CC1=CC(C)=[O]->[Pd]2([O]1)[O]C(C)=CC(C)=[O]->2.COc1cccc(OC)c1NC(=O)C(=O)O.CS(C)=O.C[Si](C)(C)[O-].[Na+]>c1ccc(C2CCN(c3cccnc3)CC2)cc1

参加物

9

反応物 2

HCID 698734-PhenylpiperidineHCID 707143-Iodopyridine

生成物 3

HCID 2519CaffeineHCID 1223802233-(4-Phenyl-1-piperidinyl)pyridine収率 0%HCID 1398883374-(4-Phenylpiperidin-1-yl)pyridine収率 0%

試薬・触媒・溶媒 4

HCID 23672319Sodium trimethylsilanolate試薬HCID 1188645032-((2,6-Dimethoxyphenyl)amino)-2-oxoacetic acid触媒HCID 178427257HCID 178427257、化合物触媒HCID 679Dimethyl Sulfoxide溶媒5 回

反応条件

温度
30 °C

後処理

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid 相を保持
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

出典と根拠

ORDレコード
ord-c6a5cf3eb06541fda311bda78fffb8e0
出典データセット
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
元リンク
出典を表示

反応ノート

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