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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1346663Generated: November 1, 2026

4-Phenylpiperidine → 3-(4-Phenyl-1-piperidinyl)pyridine

https://huagongshe.com/reaction/1346663

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-PhenylpiperidineHCID 69873—
Reactant3-IodopyridineHCID 70714—
ReagentCID 14794698HCID 14794698—
CatalystCuprous chlorideHCID 62652—
CatalystN1,N2-bis(4-hydroxy-2,6-dimethylphenyl)oxalamideHCID 126500385—
SolventDimethyl SulfoxideHCID 679—
ProductCaffeineHCID 2519—
Product3-(4-Phenyl-1-piperidinyl)pyridineHCID 1223802238.014%
Product4-(4-Phenylpiperidin-1-yl)pyridineHCID 1398883370%

Reaction Conditions

Temperature30 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-6db15f2c783f4f8f812e6b17465f40a2
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions