HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1346896Generated: November 1, 2026
4-Phenylpiperidine → 3-(4-Phenyl-1-piperidinyl)pyridine
https://huagongshe.com/reaction/1346896
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Phenylpiperidine | HCID 69873 | — |
| Reactant | 3-Iodopyridine | HCID 70714 | — |
| Reagent | Sodium trimethylsilanolate | HCID 23672319 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Catalyst | 1,3-Bis(2,6-di(pentan-3-yl)phenyl)-1H-imidazol-3-ium chloride | HCID 92132781 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Caffeine | HCID 2519 | — |
| Product | 3-(4-Phenyl-1-piperidinyl)pyridine | HCID 122380223 | 34.992% |
| Product | 4-(4-Phenylpiperidin-1-yl)pyridine | HCID 139888337 | 0% |
Provenance & Evidence
| DOI | 10.1021/jacs.6c05959 |
|---|
| Source dataset | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
| ORD ID | ord-ed26a464833a4907bf31c4310b642f82 |
|---|
| Source note | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
