HRID1347

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21866389

未命名化合物

结构：Cc1ccc(-c2ccccc2C(=O)Nc2ccc(C(=O)N3CCc4nc(C)[nH]c4-c4ccccc43)cc2)cc1

HCID178418341

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(-c2ccccc2C(=O)Nc2ccc(C(=O)N3CCc4nc(C)[nH]c4-c4ccccc43)cc2)cc1.Cl

HCID178418374

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

2-(4-Methylphenyl)-4'-[(2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepin-6-yl)carbonyl]benzanilide was dissolved in 10 ml of ethyl alcohol, the resulting solution was mixed with 0.37 ml of 4N hydrochloric acid-ethyl acetate and cooled on an ice bath and then the thus precipitated crystals were collected by filtration and washed with a small volume of ethyl alcohol to obtain 500 mg of 2-(4-methylphenyl)-4'-[(2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepin-6-yl)carbonyl]benzanilide hydrochloride (Example 19(2)).

WORKUP

后处理

temperaturecooled on an ice bath
filtrationthe thus precipitated crystals were collected by filtration
washwashed with a small volume of ethyl alcohol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-58cd2e04d7a34df7b31f8a8ce82f18d5
来源数据集: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05723606
来源说明: uspto-grants-1998_03

反应 SMILES

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:39]=[CH:38][CH:37]=[CH:36][C:9]=2[C:10]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]([N:21]3[C:27]4[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=4[C:25]4[NH:32][C:33]([CH3:35])=[N:34][C:24]=4[CH2:23][CH2:22]3)=[O:20])=[CH:15][CH:14]=2)=[O:11])=[CH:4][CH:3]=1.[ClH:40].C(OCC)(=O)C>C(O)C>[ClH:40].[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:39]=[CH:38][CH:37]=[CH:36][C:9]=2[C:10]([NH:12][C:13]2[CH:14]=[CH:15][C:16]([C:19]([N:21]3[C:27]4[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=4[C:25]4[NH:32][C:33]([CH3:35])=[N:34][C:24]=4[CH2:23][CH2:22]3)=[O:20])=[CH:17][CH:18]=2)=[O:11])=[CH:6][CH:7]=1