HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1347235Generated: November 3, 2026
3-Bromopyridine → 3-(4-Phenyl-1-piperidinyl)pyridine
https://huagongshe.com/reaction/1347235
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Bromopyridine | HCID 12286 | — |
| Reactant | 4-Phenylpiperidine | HCID 69873 | — |
| Reagent | Potassium tert-butoxide | HCID 23665647 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Catalyst | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Caffeine | HCID 2519 | — |
| Product | 3-(4-Phenyl-1-piperidinyl)pyridine | HCID 122380223 | 12.82% |
| Product | 4-(4-Phenylpiperidin-1-yl)pyridine | HCID 139888337 | 11.355% |
Provenance & Evidence
| DOI | 10.1021/jacs.6c05959 |
|---|
| Source dataset | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
| ORD ID | ord-0d4d6d6c57574325af0eba8963411295 |
|---|
| Source note | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
