3-Bromopyridine → 4-(4-Phenylpiperidin-1-yl)pyridine

HRID 1347840Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1347840
Brc1cccnc1.c1ccc(C2CCNCC2)cc1>O=C1C(=O)c2cccnc2-c2ncccc21.CC(C)(C)[O-].[K+].CS(C)=O.CS(C)=O.CS(C)=O.CS(C)=O.CS(C)=O>Cn1c(=O)c2c(ncn2C)n(C)c1=O.c1ccc(C2CCN(c3cccnc3)CC2)cc1.c1ccc(C2CCN(c3ccncc3)CC2)cc1

Komponenten

8

Edukt 2

HCID 122863-BromopyridineHCID 698734-Phenylpiperidine

Produkt 3

HCID 2519CaffeineHCID 1223802233-(4-Phenyl-1-piperidinyl)pyridineAusbeute 9,436 %HCID 1398883374-(4-Phenylpiperidin-1-yl)pyridineAusbeute 9,943 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23665647Potassium tert-butoxideReagenzHCID 728101,10-Phenanthroline-5,6-dioneKatalysatorHCID 679Dimethyl SulfoxideLösungsmittel5×

Reaktionsbedingungen

Temperatur
30 °C

Aufarbeitung

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid-Phase beibehalten
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

Quellen und Nachweise

ORD-Eintrag
ord-412073f42ce347ffb6216f41a3f40184
Quelldatensatz
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
Originallink
Quelle ansehen

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