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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1348340Generated: October 29, 2026

3-Bromopyridine → 3-(4-Phenyl-1-piperidinyl)pyridine

https://huagongshe.com/reaction/1348340

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-BromopyridineHCID 12286—
Reactant4-PhenylpiperidineHCID 69873—
ReagentSodium t-butoxideHCID 23676156—
Catalyst4,7-Dimethoxy-1,10-phenanthrolineHCID 10462298—
CatalystHCID 178486303HCID 178486303—
SolventDimethyl SulfoxideHCID 679—
ProductCaffeineHCID 2519—
Product3-(4-Phenyl-1-piperidinyl)pyridineHCID 12238022310.3%
Product4-(4-Phenylpiperidin-1-yl)pyridineHCID 1398883379.886%

Reaction Conditions

Temperature30 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-1ffdce56d2a04520a9c98a9003cca516
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions