Hydrochloric Acid → 2,2'-[(4-Methoxy-5-methyl-1,3-phenylene)diazanediyl]di(ethan-1-ol)

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Reaction Steps

33.5 g of 3,3′-(4-methoxy-5-methyl-1,3-phenylene)bis-(1,3-oxazolidin-2-one) were heated under reflux in 500 ml of 20% strength KOH for 10 h. The mixture was cooled to room temperature and poured onto 1.5 l of iced water. The mixture was then neutralized with HCl and extracted several times with ethyl acetate. The combined ethyl acetate phases were evaporated on a Rotavapor and then distilled in a Kugelrohr (250–290° C., 0.08 mbar).

Provenance & Evidence