HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,5-Diazabicyclo(4.3.0)non-5-ene → HCID 178420741, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,5-Diazabicyclo(4.3.0)non-5-ene | HCID 76349 | — |
| Reactant | Diethyl 2-(2-chloro-6-fluorophenyl)malonate | HCID 2782658 | — |
| Reactant | 1H-Imidazol-2-amine hydrochloride | HCID 12211238 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178420741 | HCID 178420741 | 44.5% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of 2.89 g of diethyl (2-chloro-6-fluorophenyl)malonate, 1.20 g of aminoimidazole hydrochloride, 2.48 g of 1,5-diazabicyclo[4.3.0]-5-nonene (DBN) and 10 ml of N,N-dimethylformamide (DMF) was heated at 100° C. for 4 hours. The reaction mixture was allowed to cool, filtered the precipitate and dried to give 1.80 g of 5,7-dihydroxy-6-(2-chloro-6-fluorophenyl)imidazo[1,2-a]pyrimidine DBN salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07211545B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-f483e3bf53794d85b2583432dbceba08 |
| Source note | uspto-grants-2007_05 |