Chloroform → HCID 11516502, compound

HRID 1348552Notes

Reaction equation

HRID 1348552 reaction equation
Cl[C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[N:5]=[C:4]([Cl:11])[C:3]=1[C:12]1[C:17]([F:18])=[CH:16][C:15]([F:19])=[CH:14][C:13]=1[F:20].[CH2:21]([NH:24][CH2:25][CH2:26][CH3:27])[CH2:22][CH3:23].C(Cl)(Cl)Cl>O>[CH2:21]([N:24]([CH2:25][CH2:26][CH3:27])[C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[N:5]=[C:4]([Cl:11])[C:3]=1[C:12]1[C:17]([F:18])=[CH:16][C:15]([F:19])=[CH:14][C:13]=1[F:20])[CH2:22][CH3:23]

Participants

5

Reactant 3

HCID 6212ChloroformHCID 8902DipropylamineHCID 230182755,7-Dichloro-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine

Product 1

HCID 11516502HCID 11516502, compoundYield 83.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 0.095 g of 5,7-dichloro-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine and 0.12 g of di-n-propylamine was heated at 80° C. for one hour. The reaction mixture was allowed to cool, and chloroform and water were added thereto. The separated organic layer was dried over sodium sulfate and concentrated. The residue was subjected to silica gel column chromatography to give 0.095 g of 5-(di-n-propylamino)-6-(2,4,6-trifluorophenyl)-7-chloroimidazo[1,2-a]pyrimidine.

Workup

  1. temperatureto cool
  2. dry with materialThe separated organic layer was dried over sodium sulfate
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-0d9028f5ce064f77a5c9decc89f5a5ab
Source dataset
uspto-grants-2007_05
Patent number
US07211545B2

Reaction notes

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