p-Fluoronitrobenzene → 4-[1-(4-Nitrophenyl)piperidin-4-yl]morpholine

HRID 1348566Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][O:10][CH2:9][CH2:8]2)[CH2:3][CH2:2]1.F[C:14]1[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][CH:15]=1>>[N+:20]([C:17]1[CH:18]=[CH:19][C:14]([N:1]2[CH2:6][CH2:5][CH:4]([N:7]3[CH2:12][CH2:11][O:10][CH2:9][CH2:8]3)[CH2:3][CH2:2]2)=[CH:15][CH:16]=1)([O-:22])=[O:21]

Participants

Reactant 2

HCID 9590p-Fluoronitrobenzene

HCID 7957244-Morpholinopiperidine

Product 1

HCID 210915824-[1-(4-Nitrophenyl)piperidin-4-yl]morpholine

Procedure

The compound was prepared from 4-piperidin-4-yl-morpholine (Example 4) and 4-fluoro-nitrobenzene (Aldrich) following the procedure used in Example 1. MS (m+H)+: 292.

Sources & evidence

ORD record: ord-2ef4eb78766f4af9970af9ad60814cb1
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07211576B2

Reaction notes

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