p-Fluoronitrobenzene → 1'-(4-Nitrophenyl)[1,4'-bipiperidin]-3-ol

HRID 1348568Notes

Reaction equation

HRID 1348568 reaction equation
[N:1]1([CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH2:6][CH2:5][CH2:4][CH:3]([OH:7])[CH2:2]1.F[C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1>>[N+:21]([C:18]1[CH:19]=[CH:20][C:15]([N:11]2[CH2:12][CH2:13][CH:8]([N:1]3[CH2:6][CH2:5][CH2:4][CH:3]([OH:7])[CH2:2]3)[CH2:9][CH2:10]2)=[CH:16][CH:17]=1)([O-:23])=[O:22]

Participants

3

Reactant 2

HCID 9590p-FluoronitrobenzeneHCID 21091574[1,4'-Bipiperidin]-3-ol

Product 1

HCID 210915781'-(4-Nitrophenyl)[1,4'-bipiperidin]-3-ol

Procedure

The compound was prepared from [1,4′]bipiperidinyl-3-ol (ChemBridge) and 4-fluoro-nitrobenzene (Aldrich) following the procedure used in Example 1. MS (m+H)+: 306.

Sources & evidence

ORD record
ord-b3683a30c9714cde8b376de6a85d0d7a
Source dataset
uspto-grants-2007_05
Patent number
US07211576B2

Reaction notes

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