HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane methanol → HCID 67076752, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Reactant | HCID 67076913 | HCID 67076913 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 67076752 | HCID 67076752 | 52.4% |
Reaction Steps
4.35 g (S)-2-tert-Butoxycarbonylamino-3-(4-fluoro-2-nitro-phenoxy)-propionic acid in 80 ml methanol were hydrogenated with 0.14 g Pd(10%)/C. Chromatography on silicagel with dichloromethane/methanol 9:1 yielded 2.08 g (52%) (S)-3-(2-amino-4-fluoro-phenoxy)-2-tert-butoxycarbonylamino-propionic acid as light brown solid, MS m/e (%): 313.0 (M−H+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07211573B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-0bfc835dd4bf481bb5bf4f5d588b1b6a |
| Source note | uspto-grants-2007_05 |