1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 67076923, compound

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Reaction Steps

1.96 g (6.24 mmol) (S)-3-(2-Amino-4-fluoro-phenoxy)-2-tert-butoxycarbonylamino-propionic acid and 1.20 g (6.24 mmol) N-(3-dimethylaminopropyl)-N′-ethyl-carbodiimid-hydrochloride in 25 ml dimethylformamide were stirred overnight at room temperature. Extraction with water/ethylacetate and removal of the solvent by distillation yielded 1.58 g (86%) ((S)-2-fluoro-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-yl)-carbamic acid tert-butyl ester, MS m/e (%): 314 (M+NH4+, 13), 297 (M+H+, 40), 241 (100), 197 (63).

Provenance & Evidence