2-Methyl-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid → HCID 58655520, compound

HRID 1348591Notes

Reaction equation

HRID 1348591 reaction equation
[NH2:1][C@@H:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:6]2[CH:11]=[CH:12][CH:13]=[C:14]([Cl:15])[C:5]=2[O:4][CH2:3]1.[CH3:16][CH:17]([C:21]([NH:23][CH2:24][C:25]([F:31])([F:30])[C:26]([F:29])([F:28])[F:27])=[O:22])[C:18](O)=[O:19]>>[Cl:15][C:14]1[C:5]2[O:4][CH2:3][C@H:2]([NH:1][C:18](=[O:19])[CH:17]([CH3:16])[C:21]([NH:23][CH2:24][C:25]([F:30])([F:31])[C:26]([F:27])([F:28])[F:29])=[O:22])[C:8](=[O:9])[N:7]([CH3:10])[C:6]=2[CH:11]=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 210724942-Methyl-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acidHCID 21091537HCID 21091537, compound

Product 1

HCID 58655520HCID 58655520, compound

Procedure

The title compounds were obtained according to the procedure described in example 2b) by condensation of (S)-7-amino-4-chloro-9-methyl-6,7-dihydro-9H-5-oxa-9-aza-benzocyclohepten-8-one with 2-methyl-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid (ex 1c).

Sources & evidence

ORD record
ord-b2ae215a66dc47eab8250af1b7b27548
Source dataset
uspto-grants-2007_05
Patent number
US07211573B2

Reaction notes

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