1,3-Difluoro-2-nitrobenzene → HCID 67076740, compound

HRID 1348596Notes

Reaction equation

HRID 1348596 reaction equation
[C:1]([O:5][C:6]([NH:8][C@@H:9]([C@H:13]([OH:15])[CH3:14])[C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19](F)[C:18]=1[N+:24]([O-:26])=[O:25]>>[C:1]([O:5][C:6]([NH:8][C@@H:9]([C@H:13]([O:15][C:19]1[CH:20]=[CH:21][CH:22]=[C:17]([F:16])[C:18]=1[N+:24]([O-:26])=[O:25])[CH3:14])[C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 879221,3-Difluoro-2-nitrobenzeneHCID 2724766N-tert-Butoxycarbonyl-L-threonine

Product 1

HCID 67076740HCID 67076740, compound

Procedure

In analogous manner to that described in example 5a), the reaction of (2S,3R)-2-tert-butoxycarbonylamino-3-hydroxy-butyric acid and 2,6-difluoro-nitrobenzene yielded (78% of theory) the title compound as a brown oil, MS m/e (%): 357.3 (M−H+, 100).

Sources & evidence

ORD record
ord-91413881f47f46178ad33251be74195a
Source dataset
uspto-grants-2007_05
Patent number
US07211573B2

Reaction notes

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