2,5-Difluoronitrobenzene → HCID 67076729, compound

HRID 1348597Notes

Reaction equation

HRID 1348597 reaction equation
[C:1]([O:5][C:6]([NH:8][C@@H:9]([C@H:13]([OH:15])[CH3:14])[C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].F[C:17]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:18]=1[N+:24]([O-:26])=[O:25]>>[C:1]([O:5][C:6]([NH:8][C@@H:9]([C@H:13]([O:15][C:17]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:18]=1[N+:24]([O-:26])=[O:25])[CH3:14])[C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 677672,5-DifluoronitrobenzeneHCID 2724766N-tert-Butoxycarbonyl-L-threonine

Product 1

HCID 67076729HCID 67076729, compound

Procedure

In analogous manner to that described in example 5a), the reaction of (2S,3R)-2-tert-butoxycarbonylamino-3-hydroxy-butyric acid and 2,5-difluoro-nitrobenzene yielded (72% of theory) the title compound as a brown oil, MS m/e (%): 357.1 (M−H+, 100).

Sources & evidence

ORD record
ord-2c1af46ed6354f79b06cf5e7f16bac3e
Source dataset
uspto-grants-2007_05
Patent number
US07211573B2

Reaction notes

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