Butylamine → HCID 21091498, compound

Participants

Reaction Steps

1.72 g (10 mmol) —2,2,5,5-Tetramethyl-[1,3]dioxane-4,6-dione and 1.02 ml butylamine were stirred in 7 ml N,N-diisopropyl-ethylamine for 18 hours at room temperature. The excess N,N-diisopropyl-ethylamine was decanted and the residue was extracted with 1N aqueous hydrochloric acid/ethylacetate. The ethylacetate phase was washed with 1N aqueous hydrochloric acid, brine and was dried over sodiumsulfate. Evaporation of the solvent and recrystallisation from dichloromethane/heptane yielded 60% N-butyl-2,2-dimethyl-malonamic acid as white solid, MS m/e (%): 188.4 (M+H+, 100).

Provenance & Evidence