4-Fluoro-3-nitrobenzotrifluoride → HCID 21091414, compound

HRID 1348616Notes

Reaction equation

HRID 1348616 reaction equation
[C:1]([O:5][C:6]([NH:8][C@@H:9]([C@H:13]([OH:15])[CH3:14])[C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].F[C:17]1[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][C:18]=1[N+:27]([O-:29])=[O:28]>>[C:1]([O:5][C:6]([NH:8][C@@H:9]([C@H:13]([O:15][C:17]1[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:24])[F:25])=[CH:19][C:18]=1[N+:27]([O-:29])=[O:28])[CH3:14])[C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 677784-Fluoro-3-nitrobenzotrifluorideHCID 2724766N-tert-Butoxycarbonyl-L-threonine

Product 1

HCID 21091414HCID 21091414, compound

Procedure

In analogous manner to that described in example 5a), the reaction of (2S,3R)-2-tert-butoxycarbonylamino-3-hydroxy-butyric acid and 1-fluoro-2-nitro-4-trifluoromethyl-benzene yielded quantitatively the title compound as a brown oil, MS m/e (%): 426.4(M+NH4+, 85).

Sources & evidence

ORD record
ord-27e0ff2cf36247ca8d861248998c7c69
Source dataset
uspto-grants-2007_05
Patent number
US07211573B2

Reaction notes

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