HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Dibenzylamino-3-(4-fluoro-2-nitro-phenoxy)-4-phenyl-butyric acid → 3-(2-Amino-4-fluoro-phenoxy)-2-dibenzylamino-4-phenyl-butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Dibenzylamino-3-(4-fluoro-2-nitro-phenoxy)-4-phenyl-butyric acid | HCID 67076838 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(2-Amino-4-fluoro-phenoxy)-2-dibenzylamino-4-phenyl-butyric acid | HCID 67076799 | — |
Reaction Steps
2.95 g (5.73 mmol) racemic (2S,3R and 2R,3S)-2-dibenzylamino-3-(4-fluoro-2-nitro-phenoxy)-4-phenyl-butyric acid in 59 ml methanol were hydrogenated with 1.76 g Raney-Nickel. Filtration and removal of the solvent by distillation yielded 2.26 g (81%) racemic (2S,3R and 2R,3S)-3-(2-amino-4-fluoro-phenoxy)-2-dibenzylamino-4-phenyl-butyric acid as light yellow oil, MS m/e (%): 485.5 (M+H+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07211573B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-89387782ee154d4ba08c6eb5b5a707b2 |
| Source note | uspto-grants-2007_05 |