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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1348633Generated: October 30, 2026

(-)-(6R,7S)-6-cyclopropyl-7-dibenzylamino-2-fluoro-6,7-dihydro-9H-5-oxa-9-aza-benzocyclohepten-8-one → (6R,7S)-7-Amino-6-cyclopropyl-2-fluoro-6,7-dihydro-9H-5-oxa-9-aza-benzocyclohepten-8-one

https://huagongshe.com/reaction/1348633

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(-)-(6R,7S)-6-cyclopropyl-7-dibenzylamino-2-fluoro-6,7-dihydro-9H-5-oxa-9-aza-benzocyclohepten-8-oneHCID 21091432—
CatalystPalladiumHCID 23938—
SolventMethanolHCID 887—
Product(6R,7S)-7-Amino-6-cyclopropyl-2-fluoro-6,7-dihydro-9H-5-oxa-9-aza-benzocyclohepten-8-oneHCID 67076824—

Reaction Steps

The title compound was prepared by hydrogenation of (−)-(6R,7S)-6-cyclopropyl-7-dibenzylamino-2-fluoro-6,7-dihydro-9H-5-oxa-9-aza-benzocyclohepten-8-one in methanol with Pd/C (10%), MS m/e (%): 235.1 (M+H+, 100).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07211573B2
Source datasetuspto-grants-2007_05
ORD IDord-09fd573965dd4f7dab7e845ca0d60462
Source noteuspto-grants-2007_05