反应详情

温度

60 °C

To 2.90 g (8.49 mmol) 2-dibenzylamino-3-hydroxy-3-methyl-butyric acid ethyl ester in 300 ml methanol were added 3.21 g (51.0 mmol) potassium hydroxide dissolved in 100 ml water. The mixture was stirred at 60° C. overnight. 500 ml saturated, aqueous sodium dihydrogenphosphate solution were added followed by extraction with ethyl acetate. Chromatography on silicagel with ethylacetate/heptan (50:50 to 100:0) yielded 1.41 g (53%) 2-dibenzylamino-3-hydroxy-3-methyl-butyric acid, MS m/e (%): 312.3 (M−H, 100).

1. extractionfollowed by extraction with ethyl acetate