HuagongsheHuagongshe Chemistry Print Report · For research reference only
(-)-(6R,7S)-7-dibenzylamino-6-ethyl-2-fluoro-6,7-dihydro-9H-5-oxa-9-aza-benzocyclohepten-8-one → (6r,7s)-7-Amino-6-ethyl-2-fluoro-6,7-dihydro-9h-5-oxa-9-aza-benzocyclohepten-8-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (-)-(6R,7S)-7-dibenzylamino-6-ethyl-2-fluoro-6,7-dihydro-9H-5-oxa-9-aza-benzocyclohepten-8-one | HCID 21091451 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (6r,7s)-7-Amino-6-ethyl-2-fluoro-6,7-dihydro-9h-5-oxa-9-aza-benzocyclohepten-8-one | HCID 21091445 | — |
Reaction Steps
The title compound was prepared in quantitative yield by hydrogenation of (−)-(6R,7S)-7-dibenzylamino-6-ethyl-2-fluoro-6,7-dihydro-9H-5-oxa-9-aza-benzocyclohepten-8-one in methanol with Pd/C (10%), MS m/e (%): 225.3 (M+H+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07211573B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-1f90bd21d11344a694833b6d111f4129 |
| Source note | uspto-grants-2007_05 |