HRID1348669
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
9.30 g (17 mmol) racemic (2S,3R and 2R,3S)-5-Benzyloxy-2-dibenzylamino-3-(4-fluoro-2-nitro-phenoxy)-pentanoic acid in 100 ml methanol were hydrogenated with 1.5 g Raney-Nickel. Filtration and removal of the solvent by distillation yielded 5.30 g (60%) (2S,3R and 2R,3S)-3-(2-amino-4-fluoro-phenoxy)-5-benzyloxy-2-dibenzylamino-pentanoic acid as foam, MS m/e (%): 529.0 (M+H+, 100).
WORKUP
后处理
- filtrationFiltration and removal of the solvent
- distillationby distillation