HCID 21091430, compound → HCID 67076812, compound

HRID 1348670Notes

Reaction equation

HRID 1348670 reaction equation
C([O:8][CH2:9][CH2:10][C@@H:11]1[C@H:17]([N:18](CC2C=CC=CC=2)CC2C=CC=CC=2)[C:16](=[O:33])[NH:15][C:14]2[CH:34]=[C:35]([F:38])[CH:36]=[CH:37][C:13]=2[O:12]1)C1C=CC=CC=1>CO.[Pd]>[NH2:18][C@@H:17]1[C:16](=[O:33])[NH:15][C:14]2[CH:34]=[C:35]([F:38])[CH:36]=[CH:37][C:13]=2[O:12][C@@H:11]1[CH2:10][CH2:9][OH:8]

Participants

4

Reactant 1

HCID 21091430HCID 21091430, compound

Product 1

HCID 67076812HCID 67076812, compoundYield 96%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The title compound was prepared in 96% yield by hydrogenation of (6R,7S)-6-(2-benzyloxy-ethyl)-7-dibenzylamino-2-fluoro-6,7-dihydro-9H-5-oxa-9-aza-benzocyclohepten-8-one in methanol with Pd/C (10%), MS m/e (%): 241.3 (M+H+, 100).

Sources & evidence

ORD record
ord-edd8b6ab2ef645ff900c9ddde7ed1dfc
Source dataset
uspto-grants-2007_05
Patent number
US07211573B2

Reaction notes

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