Sodium Azide → HCID 12971695, compound

HRID 1348680Notes

Reaction equation

HRID 1348680 reaction equation
[CH3:1][C:2]1[CH:22]=[CH:21][C:5]2[N:6](S(C3C=CC(C)=CC=3)(=O)=O)[S:7](=[O:10])(=[O:9])[O:8][C:4]=2[CH:3]=1.[N-]=[N+]=[N-].[Na+]>C(#N)C>[CH3:1][C:2]1[CH:22]=[CH:21][C:5]2[NH:6][S:7](=[O:10])(=[O:9])[O:8][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 33557Sodium AzideHCID 18533223HCID 18533223, compound

Product 1

HCID 12971695HCID 12971695, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

6-Methyl-3-(toluene-4-sulfonyl)-3H-benzo[1,2,3]oxathiazole 2,2-dioxide (100 mg, 0.295 mmol) is dissolved in acetonitrile (5 ml). A solution of sodium azide (of 20 mg, 0.29 mmol of sodium azide in 1 ml of H2O) is added to this solution, and the mixture is stirred at RT overnight. The mixture is then stirred at 60° C. for 1 h, the solvent is distilled off under reduced pressure and the residue is purified by RP chromatography.

Workup

  1. stirringThe mixture is then stirred at 60° C. for 1 h
  2. distillationthe solvent is distilled off under reduced pressure
  3. customthe residue is purified by RP chromatography

Sources & evidence

ORD record
ord-72f238eeb3e94f7ea3c7933faff0c677
Source dataset
uspto-grants-2007_05
Patent number
US07211592B2

Reaction notes

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