反应详情

温度

80 °C

To an ice-cold suspension of 4-carboxy-6-(3-fluoro-4-methylphenyl)-2H-pyridazin-3-one (5.50 g, 22.2 mmol) in methanol (100 mL) was added dropwise thionyl chloride (2.72 g, 24.4 mmol), and the mixture was stirred at 80° C. for 8 hours. The temperature of the reaction mixture was allowed to drop back to room temperature, and the solvent was distilled off under reduced pressure. Water was added to the ice-cold residue. The precipitate was collected by filtration, washed with water and dried to yield the title compound as pale yellow fine-needles (5.43 g, 92.7%).

1. customto drop back to room temperature
2. distillationthe solvent was distilled off under reduced pressure
3. additionWater was added to the ice-cold residue
4. filtrationThe precipitate was collected by filtration
5. washwashed with water
6. customdried