Ethanolamine → HCID 22562225, compound

HRID 1348720Notes

Reaction equation

HRID 1348720 reaction equation
[CH2:1]([N:5]1[C:10](=[O:11])[C:9]([CH2:12]OS(C)(=O)=O)=[CH:8][C:7]([C:18]2[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=2)=[N:6]1)[CH:2]([CH3:4])[CH3:3].[NH2:25][CH2:26][CH2:27][OH:28]>>[OH:28][CH2:27][CH2:26][NH:25][CH2:12][C:9]1[C:10](=[O:11])[N:5]([CH2:1][CH:2]([CH3:4])[CH3:3])[N:6]=[C:7]([C:18]2[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=2)[CH:8]=1

Participants

3

Reactant 2

HCID 700EthanolamineHCID 219915892-isobutyl-4-methanesulfonyloxymethyl-6-(4-methylphenyl)-2H-pyridazin-3-one

Product 1

HCID 22562225HCID 22562225, compound

Procedure

Following the procedure of Example 9(4), 2-isobutyl-4-methanesulfonyloxymethyl-6-(4-methylphenyl)-2H-pyridazin-3-one and 2-aminoethanol were reacted to yield the title compound as a slightly yellow oil (yield: 80.3%). 1H NMR(400 MHz, CDCl3)δ: 0.98(6H, d, J=6.8 Hz), 2.20–2.38(3H, m), 2.39(3H, s), 2.84(2H, t, J=5.1 Hz), 3.72(2H, t, J=5.1 Hz), 3.82(2H, d, J=1.2 Hz), 4.07(2H, d, J=7.3 Hz), 7.26(2H, d, J=8.1 Hz), 7.68(1H, s), 7.70(2H, d, J=8.1 Hz). IR(Neat) cm−1: 3429, 1652, 1601, 1519. Mass m/z: 315(M+).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-247e000be07d44fca4b4e1dcba55da65
Source dataset
uspto-grants-2007_05
Patent number
US07211577B2

Reaction notes

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