tert-Butyl piperazine-1-carboxylate → HCID 21991580, compound

HRID 1348732Notes

Reaction equation

HRID 1348732 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[C:11]([CH2:20]OS(C)(=O)=O)[C:12](=[O:19])[N:13]([CH2:15][CH:16]([CH3:18])[CH3:17])[N:14]=2)[CH:5]=[CH:6][C:7]=1[F:8].[N:26]1([C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[C:35]([O:34][C:32]([N:26]1[CH2:31][CH2:30][N:29]([CH2:20][C:11]2[C:12](=[O:19])[N:13]([CH2:15][CH:16]([CH3:17])[CH3:18])[N:14]=[C:9]([C:4]3[CH:5]=[CH:6][C:7]([F:8])=[C:2]([F:1])[CH:3]=3)[CH:10]=2)[CH2:28][CH2:27]1)=[O:33])([CH3:38])([CH3:36])[CH3:37]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 219915206-(3,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxym ethyl-2H-pyridazin-3-one

Product 1

HCID 21991580HCID 21991580, compoundYield 85.5%

Procedure

Following the procedure of Example 1(10), 6-(3,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and tert-butyl 1-piperazinecarboxylate were reacted to yield the title compound as a yellow oil (yield: 85.5%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-46042f43beb9439d9b48f91c36352001
Source dataset
uspto-grants-2007_05
Patent number
US07211577B2

Reaction notes

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