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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1348741Generated: October 29, 2026

1-Methylpiperazine → 2-cinnamyl-6-(4-fluoro-3-methylphenyl)-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-one

https://huagongshe.com/reaction/1348741

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-MethylpiperazineHCID 53167—
Reactant2-cinnamyl-6-(4-fluoro-3-methylphenyl)-4-methanesulfonyloxy methyl-2H-pyridazin-3-oneHCID 73858298—
Product2-cinnamyl-6-(4-fluoro-3-methylphenyl)-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-oneHCID 6721324180.1%

Reaction Steps

Following the procedure of Example 1(10), 2-cinnamyl-6-(4-fluoro-3-methylphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and 1-methylpiperazine were reacted to yield the title compound as a yellow oil (yield: 80.1%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07211577B2
Source datasetuspto-grants-2007_05
ORD IDord-d026e7bb2b8a46dfb645fe3b041a2346
Source noteuspto-grants-2007_05