1-(2-Hydroxyethyl)piperazine → 2-(4-chlorocinnamyl)-6-(3-fluoro-4-methoxyphenyl)-4-[4-(2-hydroxyethyl)-1-piperazinyl]methyl-2H-pyridazin-3-one

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	1-(2-Hydroxyethyl)piperazine	HCID 7677	—
Edukt	2-(4-chlorocinnamyl)-6-(3-fluoro-4-methoxyphenyl)-4-methane sulfonyloxymethyl-2H-pyridazin-3-one	HCID 73858284	—
Produkt	2-(4-chlorocinnamyl)-6-(3-fluoro-4-methoxyphenyl)-4-[4-(2-hydroxyethyl)-1-piperazinyl]methyl-2H-pyridazin-3-one	HCID 67213400	65,1%

Reaktionsschritte

Following the procedure of Example 1(10), 2-(4-chlorocinnamyl)-6-(3-fluoro-4-methoxyphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and 1-piperazineethanol were reacted to yield the title compound as slightly-yellow needles (yield: 65.1%).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07211577B2
Quelldatensatz	uspto-grants-2007_05
ORD ID	ord-d9c5413b66b94cd1867d3c4affccf418
Quellennotiz	uspto-grants-2007_05