1-Bromomethyl-2,6-dichlorobenzene → HCID 22562272, compound

HRID 1348796Notes

Reaction equation

HRID 1348796 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:15]([O:17]C)=[O:16])[C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][C:3]=1[CH3:19].[Cl:20][C:21]1[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[C:22]=1[CH2:23]Br>>[C:15]([C:10]1[C:11](=[O:14])[N:12]([CH2:23][C:22]2[C:21]([Cl:20])=[CH:28][CH:27]=[CH:26][C:25]=2[Cl:29])[N:13]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[C:3]([CH3:19])[CH:4]=2)[CH:9]=1)([OH:17])=[O:16]

Participants

3

Reactant 2

HCID 301591-Bromomethyl-2,6-dichlorobenzeneHCID 219914596-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one

Product 1

HCID 22562272HCID 22562272, compoundYield 90.3%

Procedure

Following the procedure of Example 1(6), 6-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one and 2,6-dichlorobenzyl bromide were reacted to yield a crude product. Without purification, the crude product was reacted further in accordance with the procedure of Example 1(7) to yield the title compound as a pale yellow solid (90.3%).

Workup

  1. customwere reacted
  2. customto yield a crude product
  3. customWithout purification
  4. customthe crude product was reacted further in accordance with the procedure of Example 1(7)

Sources & evidence

ORD record
ord-01dddab5b39243e5aa9a5347f5f3a430
Source dataset
uspto-grants-2007_05
Patent number
US07211577B2

Reaction notes

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