tert-Butyl piperazine-1-carboxylate → HCID 22562231, compound

HRID 1348800Notes

Reaction equation

HRID 1348800 reaction equation
[F:1][C:2]1[CH:32]=[CH:31][C:5]([CH2:6][N:7]2[C:12](=[O:13])[C:11]([CH2:14][CH2:15][CH2:16]OS(C)(=O)=O)=[CH:10][C:9]([C:22]3[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[C:24]([F:30])[CH:23]=3)=[N:8]2)=[CH:4][CH:3]=1.[N:33]1([C:39]([O:41][C:42]([CH3:45])([CH3:44])[CH3:43])=[O:40])[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1>>[C:42]([O:41][C:39]([N:33]1[CH2:38][CH2:37][N:36]([CH2:16][CH2:15][CH2:14][C:11]2[C:12](=[O:13])[N:7]([CH2:6][C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:32][CH:31]=3)[N:8]=[C:9]([C:22]3[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[C:24]([F:30])[CH:23]=3)[CH:10]=2)[CH2:35][CH2:34]1)=[O:40])([CH3:45])([CH3:44])[CH3:43]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 22562301HCID 22562301, compound

Product 1

HCID 22562231HCID 22562231, compoundYield 37.4%

Procedure

Following the procedure of Example 1(10), 2-(4-fluorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-4-(3-methanesulfonyloxypropyl)-2H-pyridazin-3-one and tert-butyl 1-piperazinecarboxylate were reacted to yield the title compound as a brown oil (yield: 37.4%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-7bbd49d9e8754d35a6ac0e49b8ddbda6
Source dataset
uspto-grants-2007_05
Patent number
US07211577B2

Reaction notes

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