Lithium Hydroxide → HCID 21091661, compound

Participants

Reaction Steps

To a solution of 4-amino-2-(4-methyl-benzylamino)-butyric acid methyl ester HCl salt (923 mg, 3.13 mmol) and DIEA (1.08 mL, 6.26 mmol) in 100 mL of DCM was added carbonyldiimidazole (760 mg, 4.69 mmol). The reaction mixture was stirred for 1 hour, after which the solvents were evaporated. The residue was dissolved in 20 mL of MeOH:H2O (2:1) solution to which was added LiOH (150 mg, 6.26 mmol). The mixture was stirred at room temperature for 3 hours and then adjusted to pH ˜7 by adding Dowex-H+ resin. The solution was filtered, the solvent was evaporated, and the residue dried under vacuum to give the desired compound of Formula 304, 3-(4-methyl-benzyl)-2-oxo-hexahydro-pyrimidine-4-carboxylic acid (520 mg, 67%), which was taken on without further purification.

Provenance & Evidence