Ammonia → HCID 10270483, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of methyl ester of 1-[4-(aminosulfonyl)phenyl]-1,4-dihydro-[1]benzopyrano[4,3-c]pyrazole-3-carboxylic acid (0.77 g, 2.0 mmol) in MeOH (50 ml) in a pressure tube, liquid NH3 (5 ml) was added. The pressure tube was sealed at RT and then heated to 60° C. overnight. The suspension became clear solution. After 24 h, the solution was cooled to RT and pressure was relieved. The solvent was removed under reduced pressure. The resulting white solids were recrystallized in MeOH, to yield pure product 1-[4-(aminosulfonyl)phenyl]-1,4-dihydro-[1]benzopyrano[4,3-c]pyrazole-3-carboxamide (0.3584 g, 48%). Mass (MH+) 137. Anal. Calc'd for C17H14O4N4S+0.4H2O: C, 54.08; H, 3.95; N, 14.86. Found: C, 54.13; H, 3.90; N, 14.86.

Provenance & Evidence