HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzyl chloride → 5-Acetyl-1-(1,3-benzodioxol-5-yl)-8-[(2-chlorobenzoyl)amino]-4,5-dihydro-1h-pyrazolo[4,3-c]quinoline-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzyl chloride | HCID 11906 | — |
| Reactant | 5-Acetyl-8-amino-1-(1,3-benzodioxol-5-yl)-4,5-dihydro-1h-pyrazolo[4,3-c]quinoline-3-carboxamide acetate | HCID 10138855 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 5-Acetyl-1-(1,3-benzodioxol-5-yl)-8-[(2-chlorobenzoyl)amino]-4,5-dihydro-1h-pyrazolo[4,3-c]quinoline-3-carboxamide | HCID 10301998 | 25% |
Reaction Steps
The title material from Example 17 (280 mg, 0.00072 mol) and 2-chlorobenzyl chloride (126 mg, 0.00072 mol, d=1.382 g/mol, 91 μL) were dissolved in pyridine (2 mL) and stirred for 4 hours. The pyridine was removed in vacuo and the resulting material was purified via HPLC to give the title compound. 95 mg (MW=529.93, 25% yield). LC/MS m/z=530.96 (m+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07211597B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-7c7d5dc851ea45d09882baa799ee63a8 |
| Source note | uspto-grants-2007_05 |