HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloronicotinic acid → HCID 10164230, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloronicotinic acid | HCID 76258 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 9969088 | HCID 9969088 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 10164230 | HCID 10164230 | 39% |
Reaction Steps
The title material from Example 24 (1.2 g, 0.0033 mol) and 2-chloro-nicotinic acid (517 mg, 0.0033 mol) were combined, under argon, in 5 mL of DMF. Diisopropyl ethyl amine (862□L, 0.00495 mol) and HATU (1.88 g, 0.00495 mol) were added and the reaction was stirred for 18 hours at room temperature. The reaction was then concentrated in vacuo, and the resulting solids were triturated with water and isolated by vacuum filtration to give the product as an off white solid. 652 mg. (MW=504.91, 39% yield). LC/MS m/z=505.7 (m+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07211597B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-9887732230484e948925c358fa94265a |
| Source note | uspto-grants-2007_05 |