HCID 21092639, compound → HCID 21092647, compound

Participants

Reaction Steps

The title material from step 3 (17 g, 0.0416 mol) was treated with Raney nickel in DMF under 25 psi at RT for 17 h. The reaction mixture was filtrated and washed with DMF. The combined filtrate and washes were concentrated under reduced pressure. The resulting residue was diluted with MeOH, sonicated at 40° C., the solid was collected by filtration, to give ethyl 8-amino-1-[1,3-benzodioxol-5-yl]-1,4-dihydrochromeno[4,3-c]pyrazole-3-carboxylate (12.3415 g, 78.3%). The product was characterized by 1H NMR, LC/MS (MH+ 380), and HPLC (98% purity).

Provenance & Evidence