Sodium Hydroxide → HCID 21092424, compound

Participants

Reaction Steps

A stirred solution of 3-{((4-methyl-2-o-tolylamino-benzoxazol-6-yl)-acetyl)-1,2,3,4-tetrahydro-isoquinolin -6-yl}-butanoic acid ethyl ester [0.1 g, Reference Example 1(a)] in ethanol (20 mL), under argon and at room temperature, was treated with sodium hydroxide solution (1 mL, 1M) and then heated at reflux temperature for 2.5 hours. The reaction mixture was evaporated to low volume (approximately 2 mL) and then treated with water (12 mL). This mixture was acidified to pH 1 by addition of hydrochloric acid (1.75 mL, 1M) and cooled in ice. The resulting solid was filtered, then washed three times with water (3 mL) and then dried at 60° C. under vacuum to give the title compound as a white solid. LC-MS: RT=3.53 minutes; MS (ES)=498 (M+H)+.

Provenance & Evidence