Hydrochloric Acid → HCID 21092456, compound

Participants

Reaction Steps

A solution of 3-(isoquinolin-6-yl)-but-2-enoic acid ethyl ester {0.5 g, Reference Example 3(a)} in ethanol (30 mL) was treated with concentrated hydrochloric acid (1.7 mL). This stirred solution was flushed with nitrogen then treated with platinum oxide (0.07 g) and then hydrogenated in the presence of hydrogen at 2 bar for 19 hours. The reaction mixture was filtered through Hyflo supercel and the filter pad was washed three times with ethanol (20 mL). The combined filtrate plus washings were evaporated to give the title compound as a pale green solid. MS (ES)=248 (M+H)+.

Provenance & Evidence