Sodium ethoxide → HCID 21092458, compound

Participants

Reaction Steps

A stirred solution of 3-(2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-butanoic acid ethyl ester {0.5 g, Reference Example 5(a)} in ethanol (30 mL), under argon, was treated with sodium ethoxide (0.25 g). After stirring at room temperature for 1 hour the reaction mixture was evaporated. The residue was treated with ethyl acetate (30 mL) and the resulting solution was washed twice with saturated ammonium chloride solution (15 mL), then dried over magnesium sulfate and then evaporated to give the title compound as a yellow gum. MS (ES)=248 (M+H)+.

Provenance & Evidence