Sodium Hydroxide → HCID 21092439, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 3-[2-(tert-butyloxycarbonylamino)-1,2,3,4-tetrahydro-isoquinolin-7-yl]-3-(pyrid-4-yl)-propionic acid methyl ester {1.46 g, Reference Example 15(b)} in ethanol (100 mL) was treated with sodium hydroxide solution (6 mL, 1N). This mixture was heated at 80° C. for 9 hours and then evaporated. The residue was partitioned between ethyl acetate and water which had been adjusted to pH 6 by addition of dilute hydrochloric acid. the aqueous phase was extracted twice with ethyl acetate and the combined organics were washed with water and then evaporated to give the title compound (0.6 g) which was used without further purification.

Provenance & Evidence