反应详情

1b (200 mg, 0.86 mmol) in 20 mL MeOH was hydrogenated over 10% Pd/C (40 mg) at 50 psi H2. The reaction mixture was filtered through a plug of Celite®, washed with MeOH and concentrated on a rotary evaporator to give 168 mg (98% yield) of 4-aminobenzoyl-1,3-dihydroimidazol-2-one 1c. MS found: (M+H)+=204.

1. filtrationThe reaction mixture was filtered through a plug of Celite®
2. washwashed with MeOH
3. concentrationconcentrated on a rotary evaporator