4-methyl-1,3-thiazole-2-sulfonyl Chloride → n-[2-(4-Methyl-thiazole-2-sulfonylamino)-ethyl]-glycine ethyl ester

HRID 1348969Notes

Reaction equation

HRID 1348969 reaction equation
Cl.Cl.[CH2:3]([O:5][C:6](=[O:12])[CH2:7][NH:8][CH2:9][CH2:10][NH2:11])[CH3:4].[CH3:13][C:14]1[N:15]=[C:16]([S:19](Cl)(=[O:21])=[O:20])[S:17][CH:18]=1>>[CH2:3]([O:5][C:6](=[O:12])[CH2:7][NH:8][CH2:9][CH2:10][NH:11][S:19]([C:16]1[S:17][CH:18]=[C:14]([CH3:13])[N:15]=1)(=[O:21])=[O:20])[CH3:4]

Participants

3

Reactant 2

HCID 116800074-methyl-1,3-thiazole-2-sulfonyl ChlorideHCID 74889816N-beta-Aminoethyl-gly-oet 2hcl

Product 1

HCID 21092760n-[2-(4-Methyl-thiazole-2-sulfonylamino)-ethyl]-glycine ethyl ester

Procedure

The title compound was synthesized by the reaction of N-(2-aminoethyl)-glycine ethyl ester 2HCl with 4-methyl-thiazole-2-sulfonyl chloride as per the procedure of example 1. 1H NMR (500 MHz; DMSO-d6) δ 7.68 (s, 1H), 4.07 (q, 2H), 3.26 (s, 2H), 3.02 (t, 2H), 2.58 (t, 2H), 2.43 (s, 3H), 1.18 (t, 3H).

Sources & evidence

ORD record
ord-ab8bbea48b804d4fae9f61544edc5858
Source dataset
uspto-grants-2007_05
Patent number
US07211668B2

Reaction notes

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