2-(5-Methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetic acid → HCID 21092812, compound

HRID 1348973Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:24])[CH2:5][NH:6][CH2:7][CH2:8][NH:9][S:10]([C:13]1[S:14][C:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[N:16][N:17]=1)(=[O:12])=[O:11])[CH3:2].[N:25]1([CH2:34][C:35](O)=[O:36])[CH:33]=[C:31]([CH3:32])[C:29](=[O:30])[NH:28][C:26]1=[O:27]>>[CH2:1]([O:3][C:4](=[O:24])[CH2:5][N:6]([CH2:7][CH2:8][NH:9][S:10]([C:13]1[S:14][C:15]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)=[N:16][N:17]=1)(=[O:12])=[O:11])[C:35](=[O:36])[CH2:34][N:25]1[CH:33]=[C:31]([CH3:32])[C:29](=[O:30])[NH:28][C:26]1=[O:27])[CH3:2]

Participants

Reactant 2

HCID 8537532-(5-Methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetic acid

HCID 21092810HCID 21092810, compound

Product 1

HCID 21092812HCID 21092812, compound

Procedure

The title compound was synthesized by the reaction of N-[2-(5-phenyl-1,3,4-thiadiazole-2-sulfonylamino)-ethyl]-glycine ethyl ester with (thymin-1-yl)-acetic acid as per the procedure of example 13. 1H NMR (500 MHz; DMSO-d6) δ 11.28 (s, 0.6H), 11.26 (s, 0.4H), 9.08 (brs, 1H), 8.05 (d, 2H), 7.66–7.57 (m, 3H), 7.32 (s, 0.6H), 7.24 (s, 0.4H), 4.65 (s, 1.2H), 4.47 (s, 0.8H), 4.32 (s, 0.8H), 4.16 (q, 0.8H), 4.06 (q, 1.2H), 4.04 (s, 1.2H), 3.56 (t, 1.2H), 3.43–3.38 (m, 2H), 3.24 (t, 0.8H), 1.73 (s, 3H), 1.21 (t, 1.2H), 1.16 (t, 1.8H).

Sources & evidence

ORD record: ord-884ce52b272e4fc1a1b22849fca0d1fe
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07211668B2

Reaction notes

Loading…