2-(5-Methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetic acid → HCID 21092728, compound

Participants

Reaction Steps

To 3 mL of DMF, were added 0.30 g (0.8 mmol) of 4-(4-methyl-thiazole-2-sulfonyl)-piperazin-2-one trifluoroacetic acid salt, 0.147 g (0.8 mmol) of (thymin-1-yl)-acetic acid and 0.458 g of PyBOP. The reaction mixture was stirred for 4 hours at room temperature. Almost of the solvent was removed in vacuo and the residue was dissolved in methylene chloride. The solution was washed with saturated sodium bicarbonate solution, water, 1N HCl, water and brine sequencially. The organic layer was concentrated and column chromatographed on silicagel to give 0.19 g (56%) of the title compound.

Provenance & Evidence