N,N-Diethylethylenediamine → HCID 131725398, compound

HRID 1349014Notes

Reaction equation

HRID 1349014 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=2)[CH2:10][C@H:9]1[C:24]([OH:26])=O)=[O:7])(C)(C)C.[C:27]1([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[CH:32]=[CH:31][C:30](C(O)=O)=[CH:29][CH:28]=1.[CH2:42]([N:44]([CH2:48][CH3:49])[CH2:45][CH2:46][NH2:47])[CH3:43]>>[C:36]1([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:37]=[CH:38][C:39]([C:6]([N:8]2[CH2:12][C:11](=[N:13][O:14][CH2:15][C:16]3[CH:17]=[CH:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=3)[CH2:10][C@H:9]2[C:24]([NH:47][CH2:46][CH2:45][N:44]([CH2:48][CH3:49])[CH2:42][CH3:43])=[O:26])=[O:7])=[CH:40][CH:41]=1

Participants

4

Reactant 3

HCID 60993N,N-DiethylethylenediamineHCID 66724(1,1'-Biphenyl)-4-carboxylic acidHCID 58714542HCID 58714542, compound

Product 1

HCID 131725398HCID 131725398, compound

Procedure

Following the general method as outlined in Example 2, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-{[(4-methoxybenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]-4-carboxylic acid, and N1,N1-diethyl-1,2-ethanediamine the title compound was obtained after column chromatography as an off-white solid as a mixture of E/Z-isomers.

Sources & evidence

ORD record
ord-7ed50c6f651d4834a462ac775e608403
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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