HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methyl-o-phenylenediamine → (3Ez,5s)-5-(1-methyl-1h-benzimidazol-2-yl)-1-[(2'-methyl[1,1'-biphenyl]-4-yl)carbonyl]-3-pyrrolidinone o-methyloxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methyl-o-phenylenediamine | HCID 78498 | — |
| Reactant | 2'-Methyl-biphenyl-4-carboxylic acid | HCID 2759815 | — |
| Reactant | (2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid | HCID 58714586 | — |
| Product | (3Ez,5s)-5-(1-methyl-1h-benzimidazol-2-yl)-1-[(2'-methyl[1,1'-biphenyl]-4-yl)carbonyl]-3-pyrrolidinone o-methyloxime | HCID 131725407 | — |
Reaction Steps
Following the general method as outlined in Example 11, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2′-methyl[1,1′-biphenyl]-4-carboxylic acid, and N1-methyl-1,2-benzenediamine, the title compound was obtained in 83% purity by HPLC. MS(ESI+): m/z=439.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07211601B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-01e02ce1209d460fbf58851e093ec483 |
| Source note | uspto-grants-2007_05 |