2,3-Diaminophenol → HCID 178502618, compound

HRID 1349024Notes

Reaction equation

HRID 1349024 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16](O)=O)=[O:7])(C)(C)C.[CH3:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[C:26]1[CH:31]=[CH:30][C:29](C(O)=O)=[CH:28][CH:27]=1.[NH2:35][C:36]1[C:41]([NH2:42])=[CH:40][CH:39]=[CH:38][C:37]=1[OH:43]>>[CH3:15][O:14][N:13]=[C:11]1[CH2:10][C@@H:9]([C:16]2[NH:35][C:36]3[C:37]([OH:43])=[CH:38][CH:39]=[CH:40][C:41]=3[N:42]=2)[N:8]([C:6]([C:29]2[CH:28]=[CH:27][C:26]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=3[CH3:19])=[CH:31][CH:30]=2)=[O:7])[CH2:12]1

Participants

4

Reactant 3

HCID 5799372,3-DiaminophenolHCID 27598152'-Methyl-biphenyl-4-carboxylic acidHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 178502618HCID 178502618, compound

Procedure

Following the general method as outlined in Example 11, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2′-methyl[1,1′-biphenyl]-4-carboxylic acid, and 2,3-diaminophenol, the title compound was obtained in 91% purity by HPLC. MS(ESI+): m/z=441.

Sources & evidence

ORD record
ord-69c01426d1a34558845b4d405a29ca4b
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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