N-Methyl-o-phenylenediamine → HCID 131725410, compound

HRID 1349026Notes

Reaction equation

HRID 1349026 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16](O)=O)=[O:7])(C)(C)C.[C:19]1([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:24]=[CH:23][C:22](C(Cl)=O)=[CH:21][CH:20]=1.[CH3:34][NH:35][C:36]1[C:37]([NH2:42])=[CH:38][CH:39]=[CH:40][CH:41]=1>>[CH3:15][O:14][N:13]=[C:11]1[CH2:10][C@@H:9]([C:16]2[N:35]([CH3:34])[C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=3[N:42]=2)[N:8]([C:6]([C:31]2[CH:30]=[CH:29][C:28]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)=[CH:33][CH:32]=2)=[O:7])[CH2:12]1

Participants

4

Reactant 3

HCID 78498N-Methyl-o-phenylenediamineHCID 841514-Phenylbenzoyl chlorideHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725410HCID 131725410, compound

Procedure

Following the general method as outlined in Example 11, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]-4carbonyl chloride, and N1-methyl-1,2-benzenediamine, the title compound was obtained in 88% purity by HPLC. MS(ESI+): m/z=425.

Sources & evidence

ORD record
ord-388d471b5aa94d09b3a3f29cff5a0817
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

Loading…